Liquid Polymer Matrices (LPMs)
“Liquid Polymer Matrices” (LPMs) are a unique class of biodegradable polymers that can be injected or implanted, which enables easy loading and controlled release of both hydrophobic and hydrophilic bioactive cargos as well as combination drugs. We are currently using LPMs to deliver multi-component immunotherapeutics including cancer vaccines. Together with our clinical partners, we are working toward clinical translation of this technology.
"Gels without Vapor Pressure: Soft, Nonaqueous, and Solvent-Free Supramolecular Biomaterials for Prospective Parenteral Drug Delivery Applications"
A. Tabet, C. Wang
Adv. Healthcare Mater. 8, 1800908 (2018)
"Polymer-Based Dual-Responsive Self-Emulsifying Nanodroplets as Potential Carriers for Poorly Soluble Drugs"
L. Zhang, Z. Zhang, W. Wang, A. Tabet, S. Hanson, L. Zhang, D. Zhu, C. Wang
ACS Appl. Bio Mater. 4, 4441–4449 (2021)
"Modular Integration of Hydrogel Neural Interfaces"
A. Tabet, M.-J. Antonini, A. Sahasrabudhe, J. Park, D. Rosenfeld, F. Koehler, H. Yuk, S. Hanson, J. A. Stinson, M. Stok, X. Zhao, C. Wang, P. Anikeeva
ACS Central Sci. 7, 1516–1523 (2021) https://doi.org/10.1021/acscentsci.1c00592
Synthetic Oncolytic Polymers
"Oncolytic Polymers”, a new class of synthetic polymeric biomaterials with intrinsic and target-modulated toxicity toward cancer cells. We are currently attempting to elucidate its anti-tumor mechanism and to optimize its efficacy by combining with other cancer therapies.
"Combination of irreversible electroporation with sustained release of a synthetic membranolytic polymer for enhanced cancer cell killing"
S. M. Hanson, B. Forsyth, C. Wang
Scientific Reports 11, 10810 (2021)
Mucoadhesive Wafers
Mucoadhesive wafers composed of binary polymer blends for sublingual delivery and preservation of protein vaccines
S. M. Hanson, S. Singh, A. Tabet, K. J. Sastry, M. Barry, C. Wang
J. Control. Release 330, 427-437 (2021)
Polymer wafers with tailored composition and structure enable delivery of proteins and genes through the oral mucosa while preserving the bioactivity of these therapeutic agents. These wafers may be particularly useful in improving global implementation of mucosal vaccination against infectious diseases.